Promising Immunosuppressive Results Through Liposomal Clodronate

By Teri Farley


Everyday a new drug is introduced into the market with manufacturers guaranteeing positive results. This right here is all too uncommon particularly in medicine where laboratory experiments and studies are conducted almost everyday. A new and remarkable form of therapy was discovered for the treatment of diseases caused by an over reactive or abnormal immune system, treatment was given using liposomal clodronate.

True enough, the results on the several studies for such therapy were very promising, offering a new hope for patient suffering from immune system abnormalities. Liposome clodronate differs from any kind of therapy as it is delivered intracellularly. With the use of several advancements in medical therapy, treatment of medical diseases have become quite sophisticated indeed.

Originally clodronic acid is biphosphonate, anti-osteoporotic drug. It was approved for the treatment and prevention of osteoporosis particularly to women and hyperparathyroidism, hypercalcemia and vertebral fracture to men. It was noticed that clodronic acid has a potent analgesic and anti inflammatory effects as it significantly reduced important inflammatory markers.

Clodronic acids is a first generation biphosphonate was originally used for the prevention and treatment of osteoporosis and reduce the risk of hyperparathyroidism, vertebral fractures, fracture related pain and hypercalcemia. It was during this time that the drug was discovered to have an effect in the immune system by reducing certain inflammatory markers.

Macrophages can be a good thing or bad thing. For an instance, in simple virus infection the macrophages will be the one to fight with the virus thus preventing further infection. But in certain autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis and so on, macrophages are fighting against your healthy cells which caused such diseases.

More so, during transplant cases transplant rejection is not uncommon as the immune system may attack the new organ transplanted to the patients. To prevent this phenomenon, medical doctors most often than not start immunosupressive treatments to suppress the immune system and prevent it from attacking the transplanted organ, or in autoimmune diseases your healthy cells.

To be able to reduce or halt these immune reactions, it will be necessary to suppress the immune system. Although this mode of treatment is not new, not all method of therapy has proved to be quite a success. Transplant rejections are still prominent and disease progression on patients with autoimmune disease is still unpreventable.

With the discovery of these new therapy, it surely increases the hope of anyone suffering from severe autoimmune diseases to achieve disease remission. This may also decrease the chances of transplant rejection to those patients scheduled for transplantation in any parts of the body. All in all, clodronic acid liposome therapy is promising a good quality of life among patients.

The liposomal clodronate is no doubt a wonder drug as far as autoimmune diseases and transplantation is concerned. Medical studies and experiments are still going on for the therapeutic effect of such therapy in anti neoplastic drugs or Cancer in particular.




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