By definition, clodronate liposome is a drug delivered using liposome (a synthetic lipid that encapsulates other substances for ease of administration into the body). Liposome is manly a medium which carries the highly hydrophilic Clodronate thus facilitating its transport into the target organ. Essentially, the aim of this type of drug administration is to achieve higher macrophage depletion after an intravenous injection of the drug.
The principle behind this new method of drug administration is based on the use of synthetic lipid (Liposome) as a Trojan horse. Once ingested, the lipid is digested by the macrophages thus releasing Clodronate. This if followed by the release of the active components such as bisphosphonates which are good inhibitors of many autoimmune conditions.
Examples of the disease this drug is expected to treat include metastatic carcinomas of the breast, multiple myeloma and osteoporosis. It is also expected to be the best solution for autoimmune hyemolitic anemia, cancers and tumors in general. Significant strides have also been made with the drug during tests as far as inhibition of macrophages activities in therapies such gene and transplantation. Even in the handling of neurological disorders, this drug will be the best.
While it is still in its testing stages, the drug will not be strange since some clodronate products are already in the market to help with the treatment of excessive blood calcium. This condition is mostly seen in cancer patients. It is however encouraging that there are few mild side effects and rarely serious complications are reported. Patients using bisphosphonate products have in the past presented with nausea, vomiting and mild stomach pains.
Most patients have also reported loss of appetite. However, in the event that this drug will present with serious conditions like hives, skin rashes or even difficult breathing it is advisable that one sees a doctor immediately. Unlike the mild symptoms that would disappear after few days, these may be signs of deep-rooted drug reactions.
Other adverse drug reactions that might be associated with this drug include mouth pain, swelling and unexplainable tiredness or weakness. Moreover, patients who develop skin rashes and hives or severe muscle cramps after taking Clodronate should seek medical attention as a matter of urgency. Since these are just pre-release precautions, one should not be discouraged, as the final product may be a very stable product with lesser side effects.
As with all bisphosphonates and prescription medicine, you are not supposed to use them in some situations. For example, individuals with known allergies to Clodronate or bisphosphonates are advised to avoid the drug. In the same line, pregnant or breastfeeding mothers should not use the drug. In addition, kidney patients and those using bisphosphonate derivates should also avoid the drugs. Lastly, individuals having gastrointestinal inflammations are not allowed to use the the drug.
There are basic rules that apply to prescription medicine, which also apply to clodronate liposome. For instance, you cannot share it with any one whether they are as sick as you are. In addition, you do not use it without express instructions from a qualified physician.
The principle behind this new method of drug administration is based on the use of synthetic lipid (Liposome) as a Trojan horse. Once ingested, the lipid is digested by the macrophages thus releasing Clodronate. This if followed by the release of the active components such as bisphosphonates which are good inhibitors of many autoimmune conditions.
Examples of the disease this drug is expected to treat include metastatic carcinomas of the breast, multiple myeloma and osteoporosis. It is also expected to be the best solution for autoimmune hyemolitic anemia, cancers and tumors in general. Significant strides have also been made with the drug during tests as far as inhibition of macrophages activities in therapies such gene and transplantation. Even in the handling of neurological disorders, this drug will be the best.
While it is still in its testing stages, the drug will not be strange since some clodronate products are already in the market to help with the treatment of excessive blood calcium. This condition is mostly seen in cancer patients. It is however encouraging that there are few mild side effects and rarely serious complications are reported. Patients using bisphosphonate products have in the past presented with nausea, vomiting and mild stomach pains.
Most patients have also reported loss of appetite. However, in the event that this drug will present with serious conditions like hives, skin rashes or even difficult breathing it is advisable that one sees a doctor immediately. Unlike the mild symptoms that would disappear after few days, these may be signs of deep-rooted drug reactions.
Other adverse drug reactions that might be associated with this drug include mouth pain, swelling and unexplainable tiredness or weakness. Moreover, patients who develop skin rashes and hives or severe muscle cramps after taking Clodronate should seek medical attention as a matter of urgency. Since these are just pre-release precautions, one should not be discouraged, as the final product may be a very stable product with lesser side effects.
As with all bisphosphonates and prescription medicine, you are not supposed to use them in some situations. For example, individuals with known allergies to Clodronate or bisphosphonates are advised to avoid the drug. In the same line, pregnant or breastfeeding mothers should not use the drug. In addition, kidney patients and those using bisphosphonate derivates should also avoid the drugs. Lastly, individuals having gastrointestinal inflammations are not allowed to use the the drug.
There are basic rules that apply to prescription medicine, which also apply to clodronate liposome. For instance, you cannot share it with any one whether they are as sick as you are. In addition, you do not use it without express instructions from a qualified physician.
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